ACTEMRA PACKAGE INSERT PDF DOWNLOAD

Find valuable ACTEMRA® (tocilizumab) information, including an ACR= American College of Rheumatology; DMARD=disease-modifying antirheumatic drug. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Actimmune (tocilizumab). 27 Oct PRODUCT MONOGRAPH. Pr. ACTEMRA. ® tocilizumab. 20 mg/mL Concentrate Solution for Infusion. mg/ mL Solution for Injection.

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This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.

Infection signs, with or without a fever, include sweating unsert chills; shortness of breath; warm, red or painful skin or sores on your body; feeling very tired; muscle aches; actemra package insert in phlegm; diarrhea or stomach pain; cough; weight loss; burning when you urinate or urinating more often than normal Any of the following conditions that may give you a higher chance of getting infections.

Increased frequency and magnitude of these elevations was observed when potentially hepatotoxic inseft e. The information contained in this section of the site is intended for U. ACTEMRA is an immunosuppressant, and treatment actemra package insert immunosuppressants may result in an increased risk of malignancies.

ACTEMRA® RA Treatment Information for Rheumatologists

You should not do both. Withdraw a volume of 0. Events of gastrointestinal GI perforation have been reported in clinical trials, primarily as complications of diverticulitis in RA patients. actemra package insert

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ACTEMRA is indicated for the treatment of active systemic juvenile idiopathic arthritis in patients 2 years of age and older. The most common events occurring during infusion were headache, nausea and hypotension, and occurring within 24 hours of infusion were dizziness and hypotension. The most common serious adverse reactions were serious infections. The rate of serious infections was 9.

This happens most actemra package insert in people actemra package insert also take nonsteroidal anti-inflammatory drugs NSAIDscorticosteroids, or methotrexate.

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In the open-label extension over an average duration of 73 weeks of treatment, the overall rate of serious infections was The information contained in this section of the site is intended for U. Infection signs, with actemra package insert without a fever, include: Click “OK” if you are a healthcare professional. Patients with invasive fungal infections may present with disseminated, rather than localized, disease. Systemic Juvenile Idiopathic Arthritis Patients less than 30 kg: Dosage Modifications ACTEMRA treatment acfemra be interrupted if a patient actemra package insert a serious infection until the infection packaage controlled.

Your healthcare provider should test you for hepatitis B before starting treatment. To mix the solution, gently invert the bag to avoid foaming. Recommended Adult Dosage Every 4 Weeks Patients who have had an inadequate response to one or more TNF antagonists When used in combination with DMARDs or as monotherapy the recommended starting dose is 4 mg per kg followed actemra package insert an increase to 8 mg per kg based on clinical response.

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Increased blood pressure also called hypertension. Gastrointestinal GI perforation — use with caution in patients who may be at increased risk.

If you have systemic juvenile idiopathic arthritis SJIA you will have blood tests done every 2 to 4 weeks during treatment. Active tuberculosis, which may present with pulmonary or extrapulmonary disease.

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Serious allergic reactions Serious allergic reactions, including death, can happen with ACTEMRA infusions or injections, even if they did not actemra package insert with an earlier infusion or injection.

Promptly evaluate patients presenting with new-onset abdominal symptoms for early identification of GI perforation.

packae Your email has been sent! Prescribers should actemfa caution in considering the use of ACTEMRA in patients with actemra package insert or recent-onset demyelinating disorders.

Do not use beyond expiration date on the container. Physicians are encouraged to register patients and pregnant women are encouraged to register themselves by calling Please see package insert for additional information and possible updates to ensure safe and effective use of this medication.

Actemra package insert SC-II, the frequency of injection-site reactions was 7.