The authors document the cytological features on fine-needle aspiration cytology of a chondroblastoma which appeared as a lytic lesion in the. Chondroblastoma is an uncommon benign cartilage producing neoplasm with a characteristic epiphyseal location. This report documents the. Chondroblastoma is a rare primary bone tumor of young people .. Fine needle aspiration cytology of chondroblastoma of bone. Cancer.

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Jaffe HL, Lichtenstein L. In the second case, due to the location of the tumor in preauricular region, cartilaginous stroma aspirated was misinterpreted as chondroid stroma of pleomorphic adenoma in the salivary gland. Accessed December 31st, In addition to this, the presence of chicken wire calcification is a useful clue to the accurate diagnosis of chondroblastoma at FNAC. J Bone Joint Surg Br ; The histogenesis of chondroblastomas is controversial, although cartilage stem cells or epiphyseal cartilage cells are presumed to be the cells of origin.

Fine needle aspiration cytology of chondroblastoma of the fibula

Cyotlogy needle aspiration cytology of chondroblastoma of the fibula. Other giant cell containing lesions that comes under differential diagnosis includes osteoclastoma that involves epiphyses of long bones, but the chondroid differentiation and chicken-wire pattern of calcification on HPE, the osteoclastic giant cells are large, more numerous than chondroblastoma and attached to the periphery of the clustered spindle cells, and the nuclei of mononuclear and multinucleated giant cells present identical morphological features; however, in contrast, the nuclei of chondroblasts differ morphologically from the smaller nuclei of osteoclast-like giant cells.

Sterling G, Wilson A. Microscopically, the tumour was cellular and consisted of sheets of uniform round-to-polygonal mononuclear cells admixed with scattered osteoclast-like giant cells. Cytology smears in both the cases showed similar findings. J Bone Joint Surg ; Other methods such as curettage alone, endoscopic curettage, endoscopic curettage with cementation, curettage with fat implantation, resection with allograft replacement, marginal resection radiofrequency ablation and osteochondral autograft transfer have also been used with some success.

The histological diagnosis of typical chondroblastoma is not difficult due to their characteristic appearance with rounded or polygonal chondroblasts, multinucleated giant cells and eosinophilic chondroid extracellular matrix with focal chicken-wire calcification.


Differential diagnosis on cytology is discussed. The authors document the cytological features cytollogy fine-needle aspiration cytology chodroblastoma a chondroblastoma which appeared chondroblastoja a lytic lesion in the upper end of the right fibula, an uncommon site, in an year-old male patient.

Tumors of bone and cartilage. Am J Clin Pathol ; Journal List J Cytol v. Histopathology in both the cases showed sheets of polygonal cells with thick cell membranes and fine pale vacuolated cytoplasm.

Schajowicz F, Gallardo H.

Case Report: Cytological diagnosis of chondroblastoma: diagnostic challenge for the cytopathologist

Previous reports have suggested that the cytological features of CMF are distinctive enough to make a confident pre-operative diagnosis on FNAC after clinico-radiological correlation. Chondrobastoma in fine needle aspirates. Chap 36, Bone tumors; — The cytomorphological findings in conjunction with clinical and radiological features help not only in the initial diagnosis but also in its further categorization.

Myxoid chondrosarcoma of sphenoid sinus and chondromyxoid fibroma of iliac bone: Characteristic magenta colored fragments of chondroid matrix were seen [ [Figure – 2] b]. Magnetic resonance imaging of leg showed abnormal marrow infiltration in medullary cavity of head and upper shaft of fibula hypo-intense on T1-weighted T2-weighted sequences and hypo-to hyper-intense on short tau inversion recovery STIR sequence, the vertical length being 8 cm approximately. Chondroblastoma is a benign cartilaginous neoplasm usually arising in the epiphyses of long bones in young participants.

However, errors in the FNAC diagnosis of this rare tumor are known to occur, with the major pitfalls being its association with aneurysmal bone cyst ABC leading to a nonrepresentative aspirate and the occurrence of a plethora of giant cell-rich lesions in the differentials. A diagnostic pitfall on aspiration cytology of Parotid. Various investigations like routine blood and urine examination, serum acid and alkaline phosphatase, serum calcium and phosphorus were within normal limits.

Fine needle aspiration cytology provides a simple, quick, easy and reliable method of preoperative diagnosis of chondroblastoma and can be used as a substitute of surgical biopsy.


The cells were oval, spindle to stellate with small oval nuclei and uniform dense chromatin. X ray showed typically lytic, centrally placed, sharply demarcated lesion with sclerotic border in the epiphysis.

Cytological diagnosis of chondroblastoma: diagnostic challenge for the cytopathologist

Fine needle aspiration cytology in the diagnosis of bone lesions. It characteristically arises in the epiphysis or epimetaphyseal region of long bones and has been reported to affect people of all ages with slight male predilection.

Radiograph showed an eccentric, expansile, lytic lesion at the metaphyseal region at upper end of tibia.

In addition to this, the presence of chicken wire calcification is a useful clue to the accurate diagnosis of chondroblastoma at FNAC. They include the neoplastic mononuclear cells chondroblastsmultinucleate giant cells and chondroid matrix. The radiological findings of cortical erosion, soft tissue extension and intra-tumoral calcification are also supporters for the diagnosis of chondrosarcoma as against CMF.

Rare Painful, often causes joint effusions and restricts joint mobility Sites: FNAC was performed by the nonaspiration technique in the first patient using a 24 gauge needle while for the second case, ultrasound-guided aspiration was done because the lesion was deep-seated. Pigmented villonodular synovitis with chondroid metaplasia, chonrdoblastoma chondroblastoma of the bone: Chap 16, Bone; — Please review our privacy policy.

Fine needle aspiration cytology of chondroblastoma of the fibula

chondronlastoma One of the two cases had an unusual cytologu in the temporomandibular region and the other was located in the epi-metaphyseal region of the right humerus. Giant cell tumor of bone. There was cortical destruction with extra-osseous extension of abnormal marrow signals abutting soft tissue and musculature namely peroneal, extensor digitorum longus, flexor hallucis longus, tibialis anterior and posterior, and soleus muscle.

Daneshbod Y, Khademi B. Foot Ankle Clin ; There was no history of trauma. J Bone Joint Surg Br.

Calcification, chondroblastoma, fine needle aspiration cytology FNACgiant cells.